The TDP2 Polyclonal Antibody (CAB18017) is a vital tool for researchers studying TDP2, an enzyme involved in DNA repair processes and maintaining genomic stability. This antibody, developed in rabbits, exhibits strong reactivity with human samples and has been rigorously validated for use in Western blot applications.TDP2 is essential for the repair of DNA damage caused by various cellular processes, including chemotherapy and environmental stressors. Its role in DNA integrity maintenance makes it a key player in cancer research and understanding drug resistance mechanisms.
By detecting and analyzing TDP2 protein levels in different cell types, this antibody enables researchers to delve deeper into the mechanisms underlying DNA repair and genomic stability.Furthermore, TDP2 has been linked to neurological disorders, making it a target of interest in neurodegenerative disease research. Investigating the functions and regulation of TDP2 with the help of this antibody may provide valuable insights into the pathogenesis of neurodegenerative conditions and potentially lead to the development of targeted therapies.
Product Name:
[KO Validated] TDP2 Rabbit Polyclonal Antibody
SKU:
CAB18017
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human TDP2 (NP_057698.2).
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.
Purification Method:
Affinity purification
Gene ID:
51567
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and TDP2 knockout (KO) HeLa cells, using [KO Validated] TDP2 Rabbit pAb (CAB18017) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
