[KO Validated] STRADA Rabbit Polyclonal Antibody (CAB18012)
- SKU:
- CAB18012
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
Product Name: | [KO Validated] STRADA Rabbit Polyclonal Antibody |
SKU: | CAB18012 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-210 of human STRADA (NP_699166.2). |
Sequence: | FLPE GGCY ELLT VIGK GFED LMTV NLAR YKPT GEYV TVRR INLE ACSN EMVT FLQG ELHV SKLF NHPN IVPY RATF IADN ELWV VTSF MAYG SAKD LICT HFMD GMNE LAIA YILQ GVLK ALDY IHHM GYVH RSVK ASHI LISV DGKV YLSG LRSN LSMI SHGQ RQRV VHDF PKYS VKVL PWLS PE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:2000 |
Synonyms: | LYK5; PMSE; Stlk; STRAD; NY-BR-96; STRAD alpha; DA |
Positive Sample: | HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 48kDa |
Observed MW: | 48kDa |
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.
Purification Method: | Affinity purification |
Gene ID: | 92335 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |