The SQSTM1/P62 Rabbit Monoclonal Antibody (CAB19700) is a valuable tool for researchers studying SQSTM1/P62, a multifunctional protein involved in various cellular processes such as selective autophagy and signal transduction. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards SQSTM1/P62 in human samples, making it ideal for Western blot applications.SQSTM1/P62 is implicated in the maintenance of cellular homeostasis and plays a crucial role in the clearance of protein aggregates and damaged organelles through autophagy. Dysregulation of SQSTM1/P62 has been linked to various diseases including neurodegenerative disorders, cancer, and metabolic diseases, making it a promising target for therapeutic interventions.
By using the SQSTM1/P62 Rabbit Monoclonal Antibody, researchers can detect and analyze SQSTM1/P62 expression in different cell types, providing valuable insights into its role in disease pathogenesis. This antibody is a valuable tool for studies in autophagy, protein degradation, and disease mechanisms, leading to advancements in drug development and potential therapeutic strategies.
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
Purification Method:
Affinity purification
Gene ID:
8878
Clone Number:
ARC0180
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using SQSTM1/p62 Rabbit mAb (CAB19700) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
