SPRY2 Rabbit Polyclonal Antibody (CAB1855)
- SKU:
- CAB1855
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | SPRY2 Rabbit Polyclonal Antibody |
SKU: | CAB1855 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SPRY2 (NP_005833.1). |
Sequence: | MEAR AQSG NGSQ PLLQ TPRD GGRQ RGEP DPRD ALTQ QVHV LSLD QIRA IRNT NEYT EGPT VVPR PGLK PAPR PSTQ HKHE RLHG LPEH RQPP RLQH SQVH |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | IGAN3; hSPRY2; SPRY2 |
Positive Sample: | U-251MG,Jurkat,Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cell projection, Cytoplasm, cytoskeleton, ruffle membrane. |
Calculated MW: | 35kDa |
Observed MW: | 38kDa |
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.
Purification Method: | Affinity purification |
Gene ID: | 10253 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |