The KO Validated SNF5 Rabbit Monoclonal Antibody (CAB3247) is a superior research tool for scientists studying SNF5, a key protein involved in chromatin remodeling and gene regulation. This rabbit monoclonal antibody has been rigorously validated for knockout validation and is highly specific to SNF5 in human samples.The antibody's superior performance in Western blot applications ensures accurate and reliable detection of SNF5, enabling researchers to explore its functions in various cellular processes. Its high sensitivity and specificity make it an excellent choice for studies in cancer biology, epigenetics, and developmental biology.
SNF5, a core subunit of the SWI/SNF chromatin remodeling complex, is crucial for regulating gene expression and maintaining chromatin structure. Dysregulation of SNF5 has been linked to various diseases, including cancer and developmental disorders. By using the KO Validated SNF5 Rabbit Monoclonal Antibody (CAB3247), researchers can gain valuable insights into the role of SNF5 in these disease contexts and potentially uncover new therapeutic targets.
The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6598
Clone Number:
ARC53139
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using SMARCB1/SNF5 Rabbit mAb (CAB3247) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:2000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
