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[KO Validated] SIRT3 Rabbit Polyclonal Antibody (CAB5718)

SKU:
CAB5718
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • KO Validated Antibodies 1 Anti-SIRT3 Antibody CAB5718KO Validated
  • KO Validated Antibodies 1 Anti-SIRT3 Antibody CAB5718KO Validated
  • KO Validated Antibodies 1 Anti-SIRT3 Antibody CAB5718KO Validated
  • KO Validated Antibodies 1 Anti-SIRT3 Antibody CAB5718KO Validated
  • KO Validated Antibodies 1 Anti-SIRT3 Antibody CAB5718KO Validated
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] SIRT3 Rabbit Polyclonal Antibody
SKU:CAB5718
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 299-399 of human SIRT3 (NP_036371.1).
Sequence:PQRF LLHV VDFP MADL LLIL GTSL EVEP FASL TEAV RSSV PRLL INRD LVGP LAWH PRSR DVAQ LGDV VHGV ESLV ELLG WTEE MRDL VQRE TGKL DGPD K
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:20 - 1:50 IF/ICC,1:50 - 1:200
Synonyms:SIR2L3; T3
Positive Sample:HepG2,HeLa,293T,Mouse liver
Conjugate:Unconjugated
Cellular Localization:Mitochondrion matrix.
Calculated MW:44kDa
Observed MW:28kDa

SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control.

Purification Method:Affinity purification
Gene ID:23410
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from HepG2 cells, using [KO Validated] SIRT3 Rabbit pAb (CAB5718) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.

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