From the product page provided, it seems the KO Validated SETD7 Polyclonal Antibody (CAB9985) is designed for research involving SETD7, an enzyme that plays a critical role in the regulation of gene expression through histone methylation. The antibody, raised in rabbits, is highly specific and sensitive for detecting SETD7 in human samples, making it suitable for various applications such as Western blotting.SETD7, also known as Histone-lysine N-methyltransferase SETD7, is a key player in epigenetic regulation and has been implicated in various biological processes including cell proliferation, differentiation, and development.
Its dysregulation has been associated with diseases such as cancer and diabetes, highlighting the importance of studying its function and activity.By using the KO Validated SETD7 Polyclonal Antibody, researchers can gain valuable insights into the role of SETD7 in normal cellular function and disease states. This antibody enables accurate detection and analysis of SETD7 protein levels, facilitating deeper understanding of its molecular mechanisms and potential therapeutic applications. Whether studying epigenetics, cancer biology, or metabolic disorders, this antibody is a valuable tool for advancing research in these areas.
Product Name:
[KO Validated] SETD7 Rabbit Polyclonal Antibody
SKU:
CAB9985
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-366 of human SETD7 (NP_085151.1).
Enables histone-lysine N-methyltransferase activity and p53 binding activity. Involved in peptidyl-lysine dimethylation and peptidyl-lysine monomethylation. Acts upstream of or within cellular response to DNA damage stimulus and heterochromatin organization. Located in chromosome and nucleolus.
Purification Method:
Affinity purification
Gene ID:
80854
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts from normal (control) and SETD7 knockout (KO) 293T cells, using [KO Validated] SETD7 antibody (CAB9985) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
