Anti-SERPINB5 Antibody (CAB19848)[KO Validated]
- SKU:
- CAB19848
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Anti-SERPINB5 Antibody (CAB19848)[KO Validated]
The SERPINB5 Polyclonal Antibody (CAB19848) is a reliable tool for studying SERPINB5, a member of the serine proteinase inhibitor family that is associated with tumorigenesis and metastasis. This rabbit polyclonal antibody is highly specific for human samples and has been validated for use in Western blot applications. By targeting the SERPINB5 protein, this antibody allows for the detection and analysis of SERPINB5 expression in various cell types, making it an ideal tool for researchers in the fields of cancer biology and oncology.
SERPINB5, also known as maspin, is a tumor suppressor protein that plays a crucial role in regulating cell migration, invasion, and angiogenesis. Its dysregulation has been linked to the development and progression of various cancers, highlighting its potential as a therapeutic target. By investigating the function of SERPINB5, researchers can gain valuable insights into the mechanisms underlying cancer progression and identify novel strategies for cancer treatment and intervention.
| Antibody Name: | Anti-SERPINB5 Antibody [KO Validated] |
| Antibody SKU: | CAB19848 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human SERPINB5. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa |
| Immunogen: | Recombinant protein of human SERPINB5. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5268 |
| Uniprot: | P36952 |
| Cellular Location: | Secreted, extracellular space |
| Calculated MW: | 25kDa/42kDa |
| Observed MW: | 42KDa |
![Anti-SERPINB5 Antibody [KO Validated] (CAB19848)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/l/047/A19848_1__76810.jpg) | Western blot analysis of extracts from normal (control) and SERPINB5 knockout (KO) HeLa cells, using SERPINB5 antibody (CAB19848) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
| Synonyms: | SERPINB5, PI5, maspin, serpin B5 |
| Background: |
| UniProt Protein Function: | maspin: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Interacts with IRF6. Normal mammary epithelial cells. Belongs to the serpin family. Ov-serpin subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 18q21.33 Cellular Component: extracellular space; cytoplasm Molecular Function:serine-type endopeptidase inhibitor activity; protein binding Biological Process: extracellular matrix organization and biogenesis; morphogenesis of an epithelium; cell motility; regulation of epithelial cell proliferation |
| UniProt Code: | P36952 |
| NCBI GenInfo Identifier: | 229462757 |
| NCBI Gene ID: | 5268 |
| NCBI Accession: | P36952.2 |
| UniProt Secondary Accession: | P36952,Q6N0B4, Q8WW89, B2R6Y4, |
| UniProt Related Accession: | P36952 |
| Molecular Weight: | 25,763 Da |
| NCBI Full Name: | Serpin B5 |
| NCBI Synonym Full Names: | serpin peptidase inhibitor, clade B (ovalbumin), member 5 |
| NCBI Official Symbol: | SERPINB5Â Â |
| NCBI Official Synonym Symbols: | PI5; maspin  |
| NCBI Protein Information: | serpin B5; PI-5; peptidase inhibitor 5; protease inhibitor 5 (maspin); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 |
| UniProt Protein Name: | Serpin B5 |
| UniProt Synonym Protein Names: | Maspin; Peptidase inhibitor 5; PI-5 |
| Protein Family: | Serpin |
| UniProt Gene Name: | SERPINB5Â Â |
| UniProt Entry Name: | SPB5_HUMAN |
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