The Ko-Validated SAV1 Rabbit Polyclonal Antibody (CAB18667) is a valuable tool for researchers studying the SAV1 protein, a key regulator of the Salvador/Warts/Hippo (SWH) signaling pathway. This pathway plays a critical role in controlling organ size, tissue growth, and tumorigenesis, making SAV1 an important target for cancer research.Raised in rabbits, this antibody is highly reactive with human samples and has been rigorously validated for use in Western blot applications. By specifically binding to the SAV1 protein, researchers can easily detect and analyze its expression in various cell types.
This makes the CAB18667 antibody ideal for investigations into the molecular mechanisms underlying cell growth, proliferation, and tumorigenesis.The SAV1 Rabbit Polyclonal Antibody is a powerful tool for uncovering the role of SAV1 in cancer development and progression. With its high specificity and sensitivity, this antibody enables researchers to further understand the SWH pathway and its implications for cancer biology. By studying SAV1 expression and function, researchers can potentially identify novel therapeutic targets for the treatment of various types of cancer.
Product Name:
[KO Validated] SAV1 Rabbit Polyclonal Antibody
SKU:
CAB18667
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 199-383 of human SAV1 (NP_068590.1).
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.
Purification Method:
Affinity purification
Gene ID:
60485
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and SAV1 knockout (KO) HeLa cells, using [KO Validated] SAV1 Rabbit pAb (CAB18667) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
