The KO Validated SAMHD1 Polyclonal Antibody (CAB7794) is a valuable tool for researchers studying SAMHD1, a protein involved in regulating cell cycle progression and immune response. This polyclonal antibody, generated in rabbits, is specifically reactive with human samples and has been validated for use in various applications, including Western blotting.SAMHD1, known for its role in inhibiting HIV-1 replication, has also been implicated in DNA repair and modulation of cellular dNTP levels. By targeting the SAMHD1 protein, this antibody enables researchers to investigate its function in different cell types and conditions, making it ideal for studies in virology, immunology, and cancer research.
The importance of SAMHD1 in regulating immune response and viral replication underscores its potential as a therapeutic target for infectious diseases and cancer. By utilizing the KO Validated SAMHD1 Polyclonal Antibody, researchers can gain insights into the molecular mechanisms underlying these processes and explore new avenues for drug development and treatment strategies.
Product Name:
[KO Validated] SAMHD1 Rabbit Polyclonal Antibody
SKU:
CAB7794
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 387-626 of human SAMHD1 (NP_056289.2).
WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
DCIP; CHBL2; HDDC1; MOP-5; SBBI88; hSAMHD1; D1
Positive Sample:
HepG2,HeLa,MCF-7,Mouse spleen
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
72kDa
Observed MW:
72kDa
This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome.
Purification Method:
Affinity purification
Gene ID:
25939
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] SAMHD1 Rabbit pAb (CAB7794) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
