The KO-Validated RhoGDI Rabbit Monoclonal Antibody is a cutting-edge tool for research involving RhoGDI, a crucial regulator of Rho GTPases involved in cell migration, adhesion, and growth. This antibody, generated specifically for use in knockout validation studies, is highly specific and sensitive for detecting RhoGDI in various experimental settings.RhoGDI, a guanine nucleotide dissociation inhibitor, plays a key role in maintaining the proper localization and activity of Rho family GTPases, which are essential for diverse cellular processes such as cytoskeletal organization and cell motility.
Dysregulation of RhoGDI expression or function has been linked to various diseases, including cancer, cardiovascular disorders, and neurological conditions.By utilizing the KO-Validated RhoGDI Rabbit Monoclonal Antibody, researchers can accurately assess the impact of RhoGDI depletion on cellular pathways and phenotypes. This antibody's specificity and reliability make it an invaluable tool for investigating the functions of RhoGDI and developing potential therapeutic strategies targeting this important regulatory protein.
Product Name:
[KO Validated] RhoGDI Rabbit Monoclonal Antibody
SKU:
CAB11556
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 70-150 of human RhoGDI (P52565).
This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
396
Clone Number:
ARC0629
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RhoGDI Rabbit mAb (CAB11556) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
