The RBAP48 Monoclonal Antibody (CAB3645) is a cutting-edge tool for researchers studying the RBAP48 protein, a key component of chromatin remodeling complexes involved in gene regulation and DNA repair. This rabbit monoclonal antibody offers high specificity and sensitivity for detecting RBAP48 in human samples, making it a valuable asset for Western blot experiments.RBAP48 is essential for maintaining proper chromatin structure and gene expression, making it a crucial player in processes like transcriptional regulation and DNA damage response.
Dysregulation of RBAP48 has been linked to a variety of diseases, including cancer and developmental disorders, highlighting its importance in biomedical research.By using the RBAP48 Monoclonal Antibody, researchers can gain a better understanding of the functions and interactions of RBAP48 in various cellular processes. This antibody opens up new possibilities for investigating the role of RBAP48 in normal biology and disease pathology, ultimately paving the way for potential therapeutic interventions targeting RBAP48-related pathways.
Product Name:
[KO Validated] RBBP4 Rabbit Monoclonal Antibody
SKU:
CAB3645
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RBBP4 (NP_005601.1).
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5928
Clone Number:
ARC0813
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using RBBP4 Rabbit mAb (CAB3645) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
