The KO Validated Rab5A Polyclonal Antibody (CAB1180) is a powerful tool for researchers studying the Rab5A protein, a key regulator of endosomal trafficking and membrane fusion processes. This antibody, produced in rabbits, demonstrates high specificity and sensitivity for detecting Rab5A in various biological samples.Rab5A is essential for the proper functioning of endocytic pathways, controlling the sorting and recycling of proteins within cells. Dysregulation of Rab5A has been implicated in various diseases, including cancer, neurodegenerative disorders, and infectious diseases.
Therefore, this antibody is valuable for investigating the role of Rab5A in disease pathogenesis and identifying potential therapeutic targets.Validated for use in Western blot applications, the Rab5A Polyclonal Antibody enables precise detection and quantification of Rab5A levels in different cell types and tissues. Its superior performance and reliability make it an indispensable tool for researchers in cell biology, molecular biology, and drug discovery seeking to unravel the complex mechanisms underlying endocytic trafficking and vesicle transport pathways.
Product Name:
[KO Validated] RAB5A Rabbit Polyclonal Antibody
SKU:
CAB1180
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human RAB5A (NP_004153.2).
Enables GDP binding activity; GTP binding activity; and GTPase activity. Involved in several processes, including amyloid-beta clearance by transcytosis; early endosome to late endosome transport; and regulation of exocytosis. Located in several cellular components, including cytoplasmic side of early endosome membrane; nucleoplasm; and terminal bouton.
Purification Method:
Affinity purification
Gene ID:
5868
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using RAB5A Rabbit pAb (CAB1180) at 1:700 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
