The KO Validated PTPN1 Polyclonal Antibody (CAB1590) is a powerful tool for researchers studying PTPN1, a protein tyrosine phosphatase involved in various cellular signaling pathways. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting PTPN1 in human samples, making it an invaluable resource for Western blot analyses.PTPN1, also known as protein tyrosine phosphatase 1B, is a key regulator of insulin signaling and metabolic pathways, making it a promising target for studies on diabetes and metabolic disorders.
By utilizing the KO Validated PTPN1 Polyclonal Antibody, researchers can gain insights into the role of PTPN1 in cell signaling and disease progression, leading to potential therapeutic strategies for diabetes and related conditions.With its reliable performance and specificity, the KO Validated PTPN1 Polyclonal Antibody is an essential tool for investigating the function and regulation of PTPN1 in various biological processes, contributing to the advancement of biomedical research in diabetes and other related fields.
Product Name:
[KO Validated] PTPN1 Rabbit Polyclonal Antibody
SKU:
CAB1590
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 281-435 of human PTPN1 (NP_002818.1).
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5770
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PTPN1 antibody (CAB1590) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
