The PSIP1 Polyclonal Antibody (CAB18037) is a valuable tool for researchers studying PSIP1, a protein involved in chromatin organization and gene regulation. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the PSIP1 protein, researchers can easily detect and analyze its expression in various cell types, making it ideal for studies in molecular biology and cancer research.PSIP1, also known as LEDGF/p75, is known for its role in tethering integration-competent lentiviral DNA to host chromatin during the viral integration process. Additionally, PSIP1 has been implicated in various cellular processes, including transcriptional regulation and DNA repair.
Its involvement in these critical pathways makes it a promising target for research into viral infections, cancer progression, and genetic disorders.By utilizing the PSIP1 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of PSIP1, ultimately advancing our understanding of its role in normal cellular physiology and disease pathology. This antibody is a versatile tool for investigating the intricate mechanisms underlying gene expression and chromatin dynamics in various biological contexts.
Product Name:
[KO Validated] PSIP1 Rabbit Polyclonal Antibody
SKU:
CAB18037
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 301-530 of human PSIP1 (NP_150091.2).
Enables DNA-binding transcription factor binding activity; chromatin binding activity; and transcription coactivator activity. Involved in mRNA 5'-splice site recognition and positive regulation of transcription by RNA polymerase II. Located in heterochromatin; nuclear periphery; and nucleoplasm.
Purification Method:
Affinity purification
Gene ID:
11168
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and PSIP1 knockout (KO) 293T cells, using [KO Validated] PSIP1 Rabbit pAb (CAB18037) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
