The S100 A11 Polyclonal Antibody (CAB5486) is a valuable tool for researchers studying the S100 A11 protein, a member of the S100 family known for its role in regulating cell proliferation, differentiation, and migration. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blotting applications. By binding to the S100 A11 protein, this antibody enables the detection and analysis of S100 A11 in various cell types, making it a versatile tool for studies in cell biology, cancer research, and inflammation.
S100 A11 is implicated in a variety of biological processes, including cell cycle regulation, apoptosis, and inflammation. Its dysregulation has been linked to diseases such as cancer, neurodegenerative disorders, and inflammatory conditions. By understanding the function and regulation of S100 A11, researchers can uncover potential therapeutic targets for these diseases and develop innovative treatment strategies. The S100 A11 Polyclonal Antibody (CAB5486) is an essential reagent for investigating the complex roles of S100 A11 in health and disease.
Product Name:
[KO Validated] S100A11 Rabbit Polyclonal Antibody
SKU:
CAB5486
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-105 of human S100A11 (NP_005611.1).
WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
MLN70; S100C; HEL-S-43; 11
Positive Sample:
BxPC-3,BT-474,LOVO,22Rv1,SKOV3,THP-1
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
12kDa
Observed MW:
12kDa
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.
Purification Method:
Affinity purification
Gene ID:
6282
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] S100A11 Rabbit pAb (CAB5486) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
