[KO Validated] Prion Protein Rabbit Polyclonal Antibody (CAB18058)
- SKU:
- CAB18058
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
Product Name: | [KO Validated] Prion Protein Rabbit Polyclonal Antibody |
SKU: | CAB18058 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-230 of human Prion Protein (NP_001073592.1). |
Sequence: | KKRP KPGG WNTG GSRY PGQG SPGG NRYP PQGG GGWG QPHG GGWG QPHG GGWG QPHG GGWG QPHG GGWG QGGG THSQ WNKP SKPK TNMK HMAG AAAA GAVV GGLG GYML GSAM SRPI IHFG SDYE DRYY RENM HRYP NQVY YRPM DEYS NQNN FVHD CVNI TIKQ HTVT TTTK GENF TETD VKMM ERVV EQMC ITQY ERES QAYY QRGS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C; in |
Positive Sample: | HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, GPI-anchor, Golgi apparatus, Lipid-anchor, Nucleus. |
Calculated MW: | 28kDa |
Observed MW: | 30kDa |
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 5621 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |