null

[KO Validated] PP2A-Aβ/PR65β/PPP2R1B Rabbit Polyclonal Antibody (CAB18089)

SKU:
CAB18089
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] PP2A-Aβ/PR65β/PPP2R1B Rabbit Polyclonal Antibody
SKU:CAB18089
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 468-667 of human PP2A-Abeta/PR65β/PP2A-Aβ/PR65β/PPP2R1B (NP_859050.1).
Sequence:YAIR EAAT NNLM KLVQ KFGT EWAQ NTIV PKVL VMAN DPNY LHRM TTLF CINA LSEA CGQE ITTK QMLP IVLK MAGD QVAN VRFN VAKS LQKI GPIL DTNA LQGE VKPV LQKL GQDE DMDV KYFA QEAI SVVA QRLR KLEF PVKD SGEP SVPR ADKN HFPR PTVP GEDM GKGP VYQL RGDT RDTL AQLG IAEL VHFS QSTD
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100
Synonyms:PR65B; PP2A-Abeta; 1B
Positive Sample:293T
Conjugate:Unconjugated
Cellular Localization:cytoplasm, extracellular exosome
Calculated MW:66kDa
Observed MW:66kDa

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described.

Purification Method:Affinity purification
Gene ID:5519
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from wild type (WT) and PP2A-Abeta/PR65β/PP2A-Aβ/PR65β/PPP2R1B knockout (KO) 293T cells, using [KO Validated] PP2A-Aβ/PR65β/PPP2R1B Rabbit pAb (CAB18089) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

Related Products