The PDCD10 Polyclonal Antibody (CAB15400) is a powerful tool for researchers studying PDCD10, a key protein involved in cellular processes such as apoptosis and angiogenesis. This antibody, developed using rabbits, exhibits excellent reactivity with human samples and has been extensively validated for use in Western blot experiments. By specifically recognizing the PDCD10 protein, it enables precise detection and analysis in a variety of cell types, making it an indispensable tool for investigations in fields such as cell biology and cancer research.PDCD10, also known as programmed cell death protein 10, plays a crucial role in regulating cell survival and blood vessel formation, making it a potential target for therapeutic interventions in diseases like cancer and cardiovascular disorders.
By understanding the functions and interactions of PDCD10, researchers can uncover new insights into the mechanisms underlying these conditions and potentially identify novel treatment strategies. The PDCD10 Polyclonal Antibody provides the precision and reliability needed to advance our knowledge of PDCD10 biology and its implications for human health.
Product Name:
[KO Validated] PDCD10 Rabbit Polyclonal Antibody
SKU:
CAB15400
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-212 of human PDCD10 (NP_009148.2).
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Purification Method:
Affinity purification
Gene ID:
11235
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and PDCD10 knockout (KO) HeLa cells, using [KO Validated] PDCD10 Rabbit pAb (CAB15400) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
