The KO Validated PAK2 Polyclonal Antibody (CAB18093) is a valuable tool for researchers studying the PAK2 protein, a key regulator of cell processes such as cell motility and proliferation. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is specifically validated for Western blot applications. By binding to the PAK2 protein, this antibody facilitates the detection and analysis of PAK2 levels in various cell types, making it ideal for studies in cell biology and cancer research.
PAK2, a member of the p21-activated kinase (PAK) family, plays a crucial role in cell signaling pathways involved in cytoskeletal dynamics and cell survival. Dysregulation of PAK2 activity has been implicated in various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions. Investigating the function of PAK2 using this antibody can provide valuable insights into its role in disease progression and help in the development of targeted therapies.
Product Name:
[KO Validated] PAK2 Rabbit Polyclonal Antibody
SKU:
CAB18093
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-212 of human PAK2 (NP_000903.2).
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
Purification Method:
Affinity purification
Gene ID:
5062
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and PAK2 knockout (KO) HeLa cells, using [KO Validated] PAK2 Rabbit pAb (CAB18093) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
