The PA2G4 Polyclonal Antibody (CAB19972) is a valuable tool for researchers studying the PA2G4 protein, which plays a key role in cell cycle regulation and proliferation. This rabbit polyclonal antibody is highly specific to human samples and has been validated for use in immunohistochemistry and Western blot applications. By binding to the PA2G4 protein, this antibody enables the detection and analysis of PA2G4 in various cell types, making it ideal for research in cancer biology and cell signaling pathways.
PA2G4, also known as Ebp1, is a multifunctional protein that is involved in various biological processes, including cell growth, differentiation, and apoptosis. Its dysregulation has been implicated in cancer development and progression, making it a promising target for cancer therapy research. By understanding the role of PA2G4 in cellular pathways, researchers can gain insights into potential therapeutic strategies for treating cancer and other related diseases.
This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified.
Purification Method:
Affinity purification
Gene ID:
5036
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and EBP1/PA2G4 knockout (KO) 293T cells, using [KO Validated] EBP1/PA2G4 Rabbit pAb (CAB19972) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
