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[KO Validated] p53 Rabbit Monoclonal Antibody (CAB19585)

SKU:
CAB19585
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] p53 Rabbit Monoclonal Antibody
SKU:CAB19585
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-393 of human p53 (NP_000537.3).
Sequence:MEEP QSDP SVEP PLSQ ETFS DLWK LLPE NNVL SPLP SQAM DDLM LSPD DIEQ WFTE DPGP DEAP RMPE AAPP VAPA PAAP TPAA PAPA PSWP LSSS VPSQ KTYQ GSYG FRLG FLHS GTAK SVTC TYSP ALNK MFCQ LAKT CPVQ LWVD STPP PGTR VRAM AIYK QSQH MTEV VRRC PHHE RCSD SDGL APPQ HLIR VEGN LRVE YLDD RNTF RHSV VVPY EPPE VGSD CTTI HYNY MCNS SCMG GMNR RPIL TIIT LEDS SGNL LGRN SFEV RVCA CPGR DRRT EEEN LRKK GEPH HELP PGST KRAL PNNT SSSP QPKK KPLD GEYF TLQI RGRE RFEM FREL NEAL ELKD AQAG KEPG GSRA HSSH LKSK KGQS TSRH KKLM FKTE GPDS D
Tested Applications:WB IP ELISA
Recommended Dilution:WB,1:500 - 1:1000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:P53; BCC7; LFS1; BMFS5; TRP53; 53
Positive Sample:293T,
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Endoplasmic reticulum, Mitochondrion matrix, Nucleus, PML body.
Calculated MW:44kDa
Observed MW:53kDa/

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

Purification Method:Affinity purification
Gene ID:7157
Clone Number:ARC56085
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from 293T cells using [KO Validated] p53 Rabbit mAb (CAB19585) at 1:1000 dilution .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020)Exposure time: 1s.

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