The KO Validated NFKB1 Polyclonal Antibody (CAB6667) is a highly specific and sensitive tool for researchers studying NFKB1, a key transcription factor involved in the regulation of immune and inflammatory responses. This antibody, generated in rabbits, is validated for use in various applications, including Western blotting, immunofluorescence, and immunohistochemistry.NFKB1, also known as NF-kappa-B p105, plays a crucial role in the activation of genes involved in immune and inflammatory signaling pathways. Dysregulation of NFKB1 has been implicated in a variety of diseases, including cancer, autoimmune disorders, and chronic inflammatory conditions.
By targeting NFKB1 with this validated antibody, researchers can gain valuable insights into the molecular mechanisms underlying these diseases, potentially leading to the development of novel therapeutic strategies.Overall, the KO Validated NFKB1 Polyclonal Antibody (CAB6667) is a reliable tool for researchers seeking to explore the role of NFKB1 in immune regulation and inflammation. Its high specificity and sensitivity make it an ideal choice for studies aimed at elucidating the molecular pathways regulated by this important transcription factor.
Product Name:
[KO Validated] NFKB1 Rabbit Polyclonal Antibody
SKU:
CAB6667
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 41-365 of human NFKB1 (NP_001158884.1).
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.
Purification Method:
Affinity purification
Gene ID:
4790
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse lung, using NFKB1 Rabbit pAb (CAB6667) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
