The NDUFS3 Polyclonal Antibody (CAB8013) is ideal for researchers studying NDUFS3, a subunit of mitochondrial complex I involved in oxidative phosphorylation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. With its ability to bind specifically to the NDUFS3 protein, researchers can accurately detect and analyze this key component of mitochondrial function in various cell types.NDUFS3 is essential for the function of complex I in the electron transport chain, making it crucial for cellular energy production.
Dysregulation of NDUFS3 has been linked to various diseases, including mitochondrial disorders and neurodegenerative conditions. By studying the expression and activity of NDUFS3 with the CAB8013 antibody, researchers can gain valuable insights into the role of mitochondrial dysfunction in disease pathology and explore potential therapeutic targets for these conditions.
Product Name:
[KO Validated] NDUFS3 Rabbit Polyclonal Antibody
SKU:
CAB8013
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 37-264 of human NDUFS3 (NP_004542.1).
This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.
Purification Method:
Affinity purification
Gene ID:
4722
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using NDUFS3 Rabbit pAb (CAB8013) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime: 90s.
