The NDUFS2 Polyclonal Antibody (CAB12858) is a valuable tool for researchers studying NDUFS2, a subunit of mitochondrial complex I involved in oxidative phosphorylation. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting NDUFS2 in human samples, making it a reliable choice for Western blot applications.NDUFS2 is essential for the proper function of complex 1 in the electron transport chain, making it crucial for cellular energy production.
Dysregulation of NDUFS2 has been linked to various human diseases, including mitochondrial disorders and neurodegenerative diseases. Therefore, the NDUFS2 Polyclonal Antibody is a valuable asset for research aimed at understanding the role of NDUFS2 in these conditions and developing potential therapeutic interventions.
Product Name:
[KO Validated] NDUFS2 Rabbit Polyclonal Antibody
SKU:
CAB12858
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 204-463 of human NDUFS2 (NP_004541.1).
The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4720
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] NDUFS2 Rabbit pAb (CAB12858) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
