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[KO Validated] NBS1/NBN Rabbit Polyclonal Antibody (CAB0783)

SKU:
CAB0783
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle
  • KO Validated Antibodies 1 Anti-NBN Antibody CAB0783KO Validated
  • KO Validated Antibodies 1 Anti-NBN Antibody CAB0783KO Validated
  • KO Validated Antibodies 1 Anti-NBN Antibody CAB0783KO Validated
$167 - $503
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Description

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Product Name:[KO Validated] NBS1/NBN Rabbit Polyclonal Antibody
SKU:CAB0783
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 520-754 of human NBS1/NBN (NP_002476.2).
Sequence:NNLF TDTD LKSI VKNS ASKS HAAE KLRS NKKR EMDD VAIE DEVL EQLF KDTK PELE IDVK VQKQ EEDV NVRK RPRM DIET NDTF SDEA VPES SKIS QENE IGKK RELK EDSL WSAK EISN NDKL QDDS EMLP KKLL LTEF RSLV IKNS TSRN PSGI NDDY GQLK NFKK FKKV TYPG AGKL PHII GGSD LIAH HARK NTEL EEWL RQEM EVQN QHAK EESL ADDL FRYN PYLK RRR
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200
Synonyms:ATV; NBS; P95; NBS1; AT-V1; AT-V2; BN
Positive Sample:293T,Mouse testis,Rat testis
Conjugate:Unconjugated
Cellular Localization:Chromosome, Nucleus, PML body, telomere.
Calculated MW:85kDa
Observed MW:95kDa/70kDa

Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Purification Method:Affinity purification
Gene ID:4683
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from wild type (WT) and NBS1/NBS1/NBN knockout (KO) 293T cells, using [KO Validated] NBS1/NBN Rabbit pAb (CAB0783) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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