[KO Validated] NBS1/NBN Rabbit Polyclonal Antibody (CAB0783)
- SKU:
- CAB0783
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | [KO Validated] NBS1/NBN Rabbit Polyclonal Antibody |
SKU: | CAB0783 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 520-754 of human NBS1/NBN (NP_002476.2). |
Sequence: | NNLF TDTD LKSI VKNS ASKS HAAE KLRS NKKR EMDD VAIE DEVL EQLF KDTK PELE IDVK VQKQ EEDV NVRK RPRM DIET NDTF SDEA VPES SKIS QENE IGKK RELK EDSL WSAK EISN NDKL QDDS EMLP KKLL LTEF RSLV IKNS TSRN PSGI NDDY GQLK NFKK FKKV TYPG AGKL PHII GGSD LIAH HARK NTEL EEWL RQEM EVQN QHAK EESL ADDL FRYN PYLK RRR |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | ATV; NBS; P95; NBS1; AT-V1; AT-V2; BN |
Positive Sample: | 293T,Mouse testis,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus, PML body, telomere. |
Calculated MW: | 85kDa |
Observed MW: | 95kDa/70kDa |
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
Purification Method: | Affinity purification |
Gene ID: | 4683 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |