The KO Validated MyD88 Rabbit Monoclonal Antibody (CAB19082) is a powerful tool for researchers studying the MyD88 protein, a key player in the signaling pathways of the innate immune system. This antibody, produced through rabbit monoclonal technology, offers high specificity and sensitivity in detecting MyD88 in various cell types and tissues.MyD88 is a critical adaptor protein involved in Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling, leading to the activation of NF-κB and MAPK pathways in response to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
Dysregulation of MyD88 signaling has been implicated in inflammatory diseases, autoimmune disorders, and cancer, making it a promising target for therapeutic interventions.This antibody has been rigorously validated for use in Western blot, immunofluorescence, and immunohistochemistry applications, providing researchers with reliable results for their studies on MyD88 function and regulation. Whether investigating immune responses, inflammatory mechanisms, or potential therapeutic strategies, the KO Validated MyD88 Rabbit Monoclonal Antibody is a valuable tool for advancing research in immunology and related fields.
Product Name:
[KO Validated] MyD88 Rabbit Monoclonal Antibody
SKU:
CAB19082
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human MyD88 (NP_002459.3).
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4615
Clone Number:
ARC52507
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and MyD88 knockout (KO) HeLa cells, using [KO Validated] MyD88 Rabbit mAb (CAB19082) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
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