[KO Validated] MMP2 Rabbit Monoclonal Antibody (CAB19080)
- SKU:
- CAB19080
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cardiovascular
Description
Product Name: | [KO Validated] MMP2 Rabbit Monoclonal Antibody |
SKU: | CAB19080 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500-600 of human MMP2 (P08253). |
Sequence: | RDKP MGPL LVAT FWPE LPEK IDAV YEAP QEEK AVFF AGNE YWIY SAST LERG YPKP LTSL GLPP DVQR VDAA FNWS KNKK TYIF AGDK FWRY NEVK KKMD P |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CLG4; MONA; CLG4A; MMP-2; TBE-1; MMP-II; MMP2 |
Positive Sample: | HCT116,U-87MG,Mouse lung,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Membrane, Mitochondrion, Nucleus, Secreted, extracellular matrix, extracellular space. |
Calculated MW: | 74kDa |
Observed MW: | 70kDa |
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 4313 |
Clone Number: | ARC0432 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |