The KO-Validated MMP2 Rabbit Monoclonal Antibody (CAB19080) is a powerful tool for researchers studying matrix metalloproteinase 2 (MMP2), an enzyme involved in extracellular matrix degradation and tissue remodeling. This antibody, generated in rabbits, shows high specificity and sensitivity for MMP2 in human samples and has been rigorously validated for use in various applications such as Western blotting.MMP2 plays a crucial role in processes such as wound healing, angiogenesis, and tumor invasion, making it a key target for cancer research and therapeutic development. The ability of this antibody to specifically bind to MMP2 allows for accurate detection and analysis of its expression levels in different cell types and tissues, providing valuable insights into the role of MMP2 in various physiological and pathological conditions.
By utilizing the KO-Validated MMP2 Rabbit Monoclonal Antibody (CAB19080), researchers can further explore the function of MMP2 and its potential as a biomarker or therapeutic target in diseases such as cancer, cardiovascular diseases, and inflammatory disorders. Its reliability and specificity make it an indispensable tool for advancing our understanding of MMP2 biology and developing novel strategies for diagnosis and treatment.
Product Name:
[KO Validated] MMP2 Rabbit Monoclonal Antibody
SKU:
CAB19080
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human MMP2 (P08253).
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
4313
Clone Number:
ARC0432
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MMP2 antibody (CAB19080) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
