[KO Validated] MC1 Receptor Rabbit Monoclonal Antibody (CAB11594)
- SKU:
- CAB11594
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | [KO Validated] MC1 Receptor Rabbit Monoclonal Antibody |
SKU: | CAB11594 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MC1 Receptor (Q01726). |
Sequence: | MAVQ GSQR RLLG SLNS TPTA IPQL GLAA NQTG ARCL EVSI SDGL FLSL GLVS LVEN ALVV ATIA KNRN LHSP MYCF ICCL ALSD LLVS GSNV LETA VILL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CMM5; MSH-R; SHEP2; MC1 Receptor |
Positive Sample: | A549,A375,C6,MCF7,Mouse kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane |
Calculated MW: | 35kDa |
Observed MW: | 35kDa |
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
Purification Method: | Affinity purification |
Gene ID: | 4157 |
Clone Number: | ARC0638 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |