The KO Validated MC1 Receptor Rabbit Monoclonal Antibody is a cutting-edge research tool designed for investigating the MC1 receptor, a G-protein coupled receptor implicated in various biological processes such as skin pigmentation and inflammation. The antibody is meticulously produced using advanced technology and validated for knockout (KO) samples, ensuring accurate and reliable results in immunohistochemistry, immunofluorescence, and flow cytometry applications.With its high specificity and sensitivity, this monoclonal antibody enables precise detection and visualization of the MC1 receptor in different tissue types and cell lines, making it an invaluable tool for researchers studying melanoma, skin disorders, and other conditions involving MC1 receptor dysregulation.
By unraveling the functions and signaling pathways associated with the MC1 receptor, this antibody contributes to advancing our understanding of physiological and pathological processes, paving the way for future therapeutic developments.
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
Purification Method:
Affinity purification
Gene ID:
4157
Clone Number:
ARC0638
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MC1 Receptor Rabbit mAb (CAB11594) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
