The KO Validated MAP2K2 Polyclonal Antibody (CAB14770) is a powerful tool for research involving MAP2K2, a key protein kinase in the MAPK signaling pathway. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples and has been rigorously validated for use in various experimental applications.MAP2K2, also known as MEK2, plays a crucial role in cell proliferation, differentiation, and survival by transmitting extracellular signals to the nucleus. Dysregulation of the MAPK pathway, in which MAP2K2 is a critical component, has been implicated in various diseases including cancer, neurodegenerative disorders, and cardiovascular diseases.
By targeting MAP2K2, researchers can gain valuable insights into the mechanisms underlying these pathologies and potentially identify new therapeutic approaches.The KO Validated MAP2K2 Polyclonal Antibody (CAB14770) is an essential tool for investigating the function and regulation of MAP2K2 in different cellular contexts. Its reliability and accuracy make it a valuable asset for studies in cell biology, signal transduction, and drug discovery, offering researchers the opportunity to deepen their understanding of MAP2K2 and its implications in human health and disease.
Product Name:
[KO Validated] MEK2 Rabbit Polyclonal Antibody
SKU:
CAB14770
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MEK2 (NP_109587.1).
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
5605
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and MEK2 knockout (KO) HeLa cells, using [KO Validated] MEK2 Rabbit pAb (CAB14770) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
