[KO Validated] MANF Rabbit Polyclonal Antibody (CAB19923)
- SKU:
- CAB19923
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | [KO Validated] MANF Rabbit Polyclonal Antibody |
SKU: | CAB19923 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-182 of human ARMET/ARP/MANF (NP_006001.4). |
Sequence: | SRAL RPGD CEVC ISYL GRFY QDLK DRDV TFSP ATIE NELI KFCR EARG KENR LCYY IGAT DDAA TKII NEVS KPLA HHIP VEKI CEKL KKKD SQIC ELKY DKQI DLST VDLK KLRV KELK KILD DWGE TCKG CAEK SDYI RKIN ELMP KYAP KAAS AR |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ARP; ARMET; NF |
Positive Sample: | 293T |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 21kDa |
Observed MW: | 16kDa |
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.
Purification Method: | Affinity purification |
Gene ID: | 7873 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |