[KO Validated] macroH2A.1 Rabbit Polyclonal Antibody (CAB18091)
- SKU:
- CAB18091
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | [KO Validated] macroH2A.1 Rabbit Polyclonal Antibody |
SKU: | CAB18091 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 123-372 of human macroH2A.1 (NP_613258.2). |
Sequence: | KLEA IITP PPAK KAKS PSQK KPVS KKAG GKKG ARKS KKKQ GEVS KAAS ADST TEGT PADG FTVL STKS LFLG QKLN LIHS EISN LAGF EVEA IINP TNAD IDLK DDLG NTLE KKGG KEFV EAVL ELRK KNGP LEVA GAAV SAGH GLPA KFVI HCNS PVWG ADKC EELL EKTV KNCL ALAD DKKL KSIA FPSI GSGR NGFP KQTA AQLI LKAI SSYF VSTM SSSI KTVY FVLF DSES IGIY VQEM AKLD AN |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100 |
Synonyms: | H2A.y; H2A/y; H2AFY; mH2A1; H2AF12M; MACROH2A1.1; macroH2A1.2; .1 |
Positive Sample: | 293T |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus. |
Calculated MW: | 39kDa |
Observed MW: | 40kDa |
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 9555 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |