The KO Validated M6PR Polyclonal Antibody (CAB19907) is a powerful tool for researchers studying M6PR, a key protein involved in intracellular trafficking and lysosomal enzyme targeting. This rabbit polyclonal antibody is highly specific and sensitive, making it ideal for Western blot applications in various cell types.M6PR, or Mannose-6-Phosphate Receptor, plays a critical role in the sorting and delivery of lysosomal enzymes to their correct destinations within the cell. Dysregulation of M6PR expression and function has been implicated in various diseases, including lysosomal storage disorders and cancer.
By using the KO Validated M6PR Polyclonal Antibody, researchers can accurately detect and analyze M6PR protein levels in their experimental systems, providing valuable insights into the role of this protein in cellular processes. This antibody is validated for use in human samples, ensuring reliable and reproducible results for studies in cell biology, biochemistry, and disease research.
Product Name:
[KO Validated] M6PR Rabbit Polyclonal Antibody
SKU:
CAB19907
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 27-185 of human M6PR (NP_002346.1).
Lysosome membrane, Single-pass type I membrane protein.
Calculated MW:
31kDa
Observed MW:
31kDa
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.
Purification Method:
Affinity purification
Gene ID:
4074
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and M6PR knockout (KO) 293T cells, using [KO Validated] M6PR Rabbit pAb (CAB19907) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
