The LTA4H Polyclonal Antibody (CAB19940) is specifically designed for research involving LTA4H, an enzyme involved in the biosynthesis of leukotriene B4, a lipid mediator with pro-inflammatory properties. This antibody, derived from rabbit serum, is highly reactive with human samples and has been validated for use in various applications, including Western blotting.LTA4H is a key player in the inflammatory response, making this antibody an invaluable tool for researchers studying inflammation, immune regulation, and related diseases such as asthma, arthritis, and inflammatory bowel disease.
By binding to the LTA4H protein, this antibody allows for the detection and analysis of LTA4H in different cell types, aiding in the understanding of its role in immune response modulation.Overall, the LTA4H Polyclonal Antibody (CAB19940) is essential for advancing research in immunology and inflammatory diseases, providing researchers with a reliable tool for investigating the mechanisms behind inflammation and potentially identifying new therapeutic targets for treating these conditions.
Product Name:
[KO Validated] LTA4H Rabbit Polyclonal Antibody
SKU:
CAB19940
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 312-611 of human LTA4H (NP_000886.1).
The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4048
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and LTA4H knockout (KO) 293T cells, using [KO Validated] LTA4H Rabbit pAb (CAB19940) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
