The Galectin-3 (LGALS3) Polyclonal Antibody (CAB13506) is specifically designed for research involving LGALS3, a protein involved in various biological processes, including cell adhesion, cell activation, and apoptosis. The antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. LGALS3, also known as Gal-3, is a member of the galectin family of proteins and plays a crucial role in inflammation, fibrosis, and cancer progression. Its involvement in these processes makes it a valuable target for research in immunology and oncology.
By detecting and analyzing LGALS3 protein levels in various cell types, this antibody facilitates the study of its function and potential therapeutic applications.Understanding the role of LGALS3 in disease pathology can provide insights into developing targeted therapies for conditions such as inflammation-related diseases, fibrosis, and cancer. With the ability to specifically bind to LGALS3, this antibody is a valuable tool for researchers looking to elucidate the molecular mechanisms underlying these conditions.
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3958
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and Galectin 3/Galectin 3/LGALS3 knockout (KO) HeLa cells, using [KO Validated] Galectin 3/LGALS3 Rabbit pAb (CAB13506) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
