The KO Validated Lamtor1 Polyclonal Antibody (CAB19983) is a valuable tool for researchers studying Lamtor1, a key regulatory protein involved in the lysosomal mTORC1 signaling pathway. This rabbit polyclonal antibody is highly specific and reactive with human samples, validated for use in a variety of applications including Western blot analysis.Lamtor1, also known as p18, is a critical component of the Ragulator complex that regulates mTORC1 activation in response to amino acid availability. Dysregulation of this pathway has been implicated in various diseases including cancer, metabolic disorders, and neurodegenerative diseases.
The KO Validated Lamtor1 Polyclonal Antibody enables precise detection and analysis of Lamtor1 protein levels in different cell types, making it an invaluable tool for researchers investigating the molecular mechanisms underlying these diseases.By utilizing this antibody, researchers can gain insights into the role of Lamtor1 in cellular signaling pathways and potential therapeutic targets for diseases associated with mTORC1 dysregulation. Its specificity and reliability make it a valuable resource for studies in cell biology, biochemistry, and therapeutic development.
Product Name:
[KO Validated] LAMTOR1 Rabbit Polyclonal Antibody
SKU:
CAB19983
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-161 of human LAMTOR1 (NP_060377.1).
Cell membrane, Cytoplasmic side, Late endosome membrane, Lipid-anchor, Lysosome membrane.
Calculated MW:
18kDa
Observed MW:
18kDa
Enables GTPase binding activity. Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of TOR signaling; and regulation of cholesterol transport. Located in lysosome. Part of Ragulator complex.
Purification Method:
Affinity purification
Gene ID:
55004
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and LAMTOR1 knockout (KO) HeLa cells, using [KO Validated] LAMTOR1 Rabbit pAb (CAB19983) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
