[KO Validated] L1CAM Rabbit Polyclonal Antibody (CAB8555)
- SKU:
- CAB8555
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | [KO Validated] L1CAM Rabbit Polyclonal Antibody |
SKU: | CAB8555 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1143-1257 of human CD171/L1CAM (NP_000416.1). |
Sequence: | IKRS KGGK YSVK DKED TQVD SEAR PMKD ETFG EYRS LESD NEEK AFGS SQPS LNGD IKPL GSDD SLAD YGGS VDVQ FNED GSFI GQYS GKKE KEAA GGND SSGA TSPI NPAV ALE |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | S10; HSAS; HYCX; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1; CD171/L1CAM |
Positive Sample: | U-251MG,Neuro-2a,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cell projection, Single-pass type I membrane protein, growth cone. |
Calculated MW: | 140kDa |
Observed MW: | 85kDa/200-250kDa |
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.
Purification Method: | Affinity purification |
Gene ID: | 3897 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |