The KO-validated JAK1 Polyclonal Antibody (CAB18323) is an essential tool for research involving JAK1, a key signaling molecule involved in various cellular processes, including immune response and cell growth. This antibody, generated in rabbits, is highly specific for human samples and has been rigorously validated for use in Western blot applications.JAK1 is a member of the Janus kinase family of proteins and plays a critical role in mediating signaling pathways activated by cytokines and growth factors. Dysregulation of JAK1 signaling has been implicated in various diseases, including cancer and immune disorders.
The KO-validated JAK1 Polyclonal Antibody enables precise detection and analysis of JAK1 protein levels in different cell types, making it an invaluable resource for researchers studying signal transduction pathways and exploring potential therapeutic targets.By using the KO-validated JAK1 Polyclonal Antibody, researchers can gain insights into the regulation of JAK1 activity and its impact on cellular functions. This antibody is a valuable tool for investigating the role of JAK1 in disease pathogenesis and developing targeted therapies that modulate JAK1 signaling for therapeutic purposes.
Product Name:
[KO Validated] JAK1 Rabbit Polyclonal Antibody
SKU:
CAB18323
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 30-300 of human JAK1 (NP_002218.2).
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3716
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of NIH/3T3, using JAK1 Rabbit pAb (CAB18323) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
