[KO Validated] JAK1 Rabbit Polyclonal Antibody (CAB18323)
- SKU:
- CAB18323
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | [KO Validated] JAK1 Rabbit Polyclonal Antibody |
SKU: | CAB18323 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 30-300 of human JAK1 (NP_002218.2). |
Sequence: | EAPE PGVE VIFY LSDR EPLR LGSG EYTA EELC IRAA QACR ISPL CHNL FALY DENT KLWY APNR TITV DDKM SLRL HYRM RFYF TNWH GTND NEQS VWRH SPKK QKNG YEKK KIPD ATPL LDAS SLEY LFAQ GQYD LVKC LAPI RDPK TEQD GHDI ENEC LGMA VLAI SHYA MMKK MQLP ELPK DISY KRYI PETL NKSI RQRN LLTR MRIN NVFK DFLK EFNN KTIC DSSV STHD LKVK YLAT LETL TKHY GAEI FETS MLLI SSEN EMN |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IF/ICC,1:100 - 1:500 |
Synonyms: | JTK3; AIIDE; JAK1A; JAK1B; JAK1 |
Positive Sample: | NIH/3T3 |
Cellular Localization: | Endomembrane system, Peripheral membrane protein. |
Calculated MW: | 133kDa |
Observed MW: | 133kDa |
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 3716 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |