The IRF3 Rabbit Monoclonal Antibody (CAB19717) is a valuable tool for researchers studying interferon regulatory factor 3 (IRF3), an essential transcription factor involved in the induction of interferons and other immune response genes. This antibody, generated in rabbits, demonstrates high specificity and sensitivity for detecting IRF3 in human samples, making it suitable for applications such as Western blotting.IRF3 plays a crucial role in the innate immune response to viral infections, as it regulates the expression of genes involved in antiviral defense mechanisms.
Dysregulation of IRF3 signaling has been implicated in various diseases, including viral infections, autoimmune disorders, and inflammatory diseases. By targeting IRF3, researchers can gain valuable insights into the underlying mechanisms of these conditions and potentially develop new therapeutic strategies.This IRF3 Rabbit Monoclonal Antibody (CAB19717) provides researchers with a reliable tool to investigate the function and regulation of IRF3 in various biological contexts, furthering our understanding of the immune response and its implications for human health.
Product Name:
[KO Validated] IRF3 Rabbit Monoclonal Antibody
SKU:
CAB19717
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human IRF3 (Q14653).
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7.
Purification Method:
Affinity purification
Gene ID:
3661
Clone Number:
ARC0198
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and IRF3 knockout (KO) HeLa cells, using [KO Validated] IRF3 Rabbit mAb (CAB19717) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
