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[KO Validated] IL6ST Rabbit Polyclonal Antibody (CAB18036)

SKU:
CAB18036
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
  • KO Validated Antibodies 1 Anti-IL-6ST Antibody CAB18036KO Validated
  • KO Validated Antibodies 1 Anti-IL-6ST Antibody CAB18036KO Validated
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] IL6ST Rabbit Polyclonal Antibody
SKU:CAB18036
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 751-918 of human IL6ST (NP_002175.2).
Sequence:QNTS STVQ YSTV VHSG YRHQ VPSV QVFS RSES TQPL LDSE ERPE DLQL VDHV DGGD GILP RQQY FKQN CSQH ESSP DISH FERS KQVS SVNE EDFV RLKQ QISD HISQ SCGS GQMK MFQE VSAA DAFG PGTE GQVE RFET VGME AATD EGMP KSYL PQTV RQGG YMPQ
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200
Synonyms:CD130; GP130; HIES4; IMD94; STWS2; CDW130; HIES4A; HIES4B; IL-6RB; sGP130; IL6ST
Positive Sample:Mouse liver,Rat liver
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:104kDa
Observed MW:150kDa

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.

Purification Method:Affinity purification
Gene ID:3572
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using IL6ST Rabbit pAb (CAB18036) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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