The IL-6ST Polyclonal Antibody (CAB18036) is a high-quality antibody designed for research involving IL-6ST, a key cell surface receptor involved in the regulation of immune responses and inflammation. This antibody is raised in rabbits and has been validated for use in various applications, including Western blotting.IL-6ST, also known as gp130, plays a critical role in the signaling pathways of interleukin-6 (IL-6) and related cytokines, which are involved in a variety of physiological and pathological processes, including inflammation, immune response, and cancer progression. By targeting IL-6ST with this antibody, researchers can effectively detect and analyze the expression and function of this important receptor in different cell types.
The IL-6ST Polyclonal Antibody is an invaluable tool for studies in immunology, cancer research, and inflammatory diseases. By understanding the signaling mechanisms mediated by IL-6ST, researchers can gain insights into potential therapeutic targets for conditions such as cancer, autoimmune disorders, and chronic inflammatory diseases. This antibody provides researchers with a reliable means to explore the role of IL-6ST in these contexts and advance our understanding of its potential as a therapeutic target.
Product Name:
[KO Validated] IL6ST Rabbit Polyclonal Antibody
SKU:
CAB18036
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 751-918 of human IL6ST (NP_002175.2).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
104kDa
Observed MW:
150kDa
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.
Purification Method:
Affinity purification
Gene ID:
3572
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using IL6ST Rabbit pAb (CAB18036) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
