The IKBKG Polyclonal Antibody (CAB12536) is a powerful tool for researchers studying the IKBKG protein, also known as NEMO, a key regulator of the NF-kappa-B pathway. This antibody is raised in rabbits and has been validated for use in various applications, including Western blot and immunohistochemistry.The IKBKG protein plays a central role in the activation of NF-kappa-B, a transcription factor that regulates genes involved in inflammation, immunity, cell proliferation, and apoptosis. Dysregulation of the NF-kappa-B pathway has been implicated in various diseases, including cancer, inflammatory disorders, and autoimmune conditions.
By using the IKBKG Polyclonal Antibody, researchers can detect and analyze the expression of IKBKG in different cell types and tissues, helping to further understand its function in both normal physiological processes and disease states. This antibody is an essential tool for studies in immunology, cancer research, and inflammatory conditions, providing valuable insights into the role of IKBKG in health and disease.
Product Name:
[KO Validated] IKKγ Rabbit Polyclonal Antibody
SKU:
CAB12536
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-419 of human IKKγ (NP_003630.1).
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
Purification Method:
Affinity purification
Gene ID:
8517
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] IKKγ Rabbit pAb (CAB12536) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
