[KO Validated] Insulin-degrading enzyme (IDE) Rabbit Polyclonal Antibody (CAB1630)
- SKU:
- CAB1630
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | [KO Validated] Insulin-degrading enzyme (IDE) Rabbit Polyclonal Antibody |
SKU: | CAB1630 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human Insulin-degrading enzyme (Insulin-degrading enzyme (IDE)) (NP_004960.2). |
Sequence: | MRYR LAWL LHPA LPST FRSV LGAR LPPP ERLC GFQK KTYS KMNN PAIK RIGN HITK SPED KREY RGLE LANG IKVL LISD PTTD KSSA ALDV HIGS LSDP PNIA GLSH FCEH MLFL GTKK YPKE NEYS QFLS EHAG SSNA FTSG EHTN YYFD VSHE HLEG ALDR FAQF FLCP LFDE SCKD REVN AVDS EHEK NVMN DAWR LFQL EKAT GNPK HPFS KFGT GNKY TLET RPNQ EGID VRQE LLKF HSAY YS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:10 - 1:100 |
Synonyms: | INSULYSIN; E) |
Positive Sample: | DU145,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Secreted. |
Calculated MW: | 118kDa |
Observed MW: | 118kDa |
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.
Purification Method: | Affinity purification |
Gene ID: | 3416 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |