The KO Validated HUR/ELAVL1 Rabbit Monoclonal Antibody (CAB19622) is a powerful tool for researchers studying the HUR/ELAVL1 protein, which plays a key role in post-transcriptional regulation of gene expression. This antibody, raised in rabbits, is highly specific and has been rigorously validated for knockout (KO) studies, ensuring reliable results.HUR/ELAVL1, also known as HuR, is a RNA-binding protein involved in mRNA stabilization and translation. Its dysregulation has been linked to various diseases, including cancer and inflammatory disorders, making it a promising target for therapeutic interventions. This antibody enables precise detection and analysis of HUR/ELAVL1 in different cell types, paving the way for deeper insights into its function and potential therapeutic applications.
Whether investigating the role of HUR/ELAVL1 in cancer progression or exploring its impact on inflammatory pathways, this monoclonal antibody provides researchers with a versatile tool for advancing their understanding of this important protein. Compatible with various experimental techniques, including Western blot and immunofluorescence, this antibody is a valuable asset for studies in molecular biology, oncology, and immunology.
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.
Purification Method:
Affinity purification
Gene ID:
1994
Clone Number:
ARC0101
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and HuR/ELAVL1 knockout (KO) 293T cells, using [KO Validated] HuR/ELAVL1 Rabbit mAb (CAB19622) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
