The HSPB1 Polyclonal Antibody (CAB16332) is specially designed for research involving HSPB1, a heat shock protein that plays a crucial role in cellular stress response and protein folding. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the HSPB1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an ideal tool for studies in cell biology and molecular biology research.HSPB1, also known as heat shock protein 27 (Hsp27), is involved in protecting cells from stress-induced damage and maintaining protein homeostasis.
Its importance in cellular stress response makes it a key player in research related to neurodegenerative diseases, cancer, and cardiovascular disorders. Investigating the function of HSPB1 is essential for developing potential therapies that target cellular stress pathways and protein quality control mechanisms.Overall, the HSPB1 Polyclonal Antibody (CAB16332) is a valuable tool for researchers looking to explore the role of HSPB1 in various cellular processes and diseases, with the potential to uncover new insights and therapeutic targets in the field of biomedical research.
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
Purification Method:
Affinity purification
Gene ID:
3315
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts from normal (control) and HSP27/HSP27/HSPB1 knockout (KO) HeLa cells, using HSP27/HSP27/HSPB1 antibody (CAB16332) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
