The HPCAL1 Polyclonal Antibody (CAB19964) is a valuable tool for researchers studying HPCAL1, a protein involved in calcium signaling and neuronal function. This rabbit-derived antibody is highly specific for HPCAL1 in human samples and has been validated for use in Western blot applications. By binding to HPCAL1, this antibody enables the detection and analysis of this protein in various cell types, making it an excellent choice for studies in neuroscience and neurodegenerative diseases.HPCAL1, also known as neuronal calcium sensor 1, plays a crucial role in regulating calcium-dependent signaling pathways in the brain. Dysregulation of HPCAL1 has been implicated in neurological disorders such as Alzheimer's disease and schizophrenia.
By studying the function of HPCAL1, researchers can gain insights into the mechanisms underlying these conditions and potentially develop new therapeutic strategies.Overall, the HPCAL1 Polyclonal Antibody is a reliable tool for investigating the role of HPCAL1 in neuronal function and neurodegenerative diseases. Its high specificity and validated performance in Western blot applications make it a valuable asset for researchers seeking to better understand the complex molecular mechanisms governing brain health and disease.
Product Name:
[KO Validated] HPCAL1 Rabbit Polyclonal Antibody
SKU:
CAB19964
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-193 of human HPCAL1 (NP_002140.2).
The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. Several alternatively spliced transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3241
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and HPCAL1 knockout (KO) HeLa cells, using [KO Validated] HPCAL1 Rabbit pAb (CAB19964) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
