The HMGB1 Rabbit Monoclonal Antibody (CAB19529) is a powerful tool for researchers studying HMGB1, a crucial protein involved in inflammation, immunity, and cancer progression. This antibody, developed using rabbit monoclonal technology, is highly specific for human samples and has been rigorously validated for use in Western blot applications.HMGB1, also known as High Mobility Group Box 1 protein, functions as a damage-associated molecular pattern (DAMP) molecule, released in response to tissue damage and inflammation. It plays a key role in activating immune responses and promoting inflammatory pathways.
Due to its involvement in various disease states, including cancer, autoimmune disorders, and sepsis, HMGB1 is an important target for therapeutic development.By using the HMGB1 Rabbit Monoclonal Antibody (CAB19529), researchers can accurately detect and analyze HMGB1 protein levels in different cell types, shedding light on its role in disease progression and immune regulation. This antibody is an essential tool for advancing our understanding of HMGB1 biology and exploring new therapeutic strategies in immunology and oncology research.
Product Name:
[KO Validated] HMGB1 Rabbit Monoclonal Antibody
SKU:
CAB19529
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human HMGB1 (P09429).
This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein.
Purification Method:
Affinity purification
Gene ID:
3146
Clone Number:
ARC0001
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HMGB1 antibody (CAB19529) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
