The KO validated HELLS Polyclonal Antibody (CAB5831) is a valuable tool for researchers studying the HELLS protein, a member of the SNF2 family of chromatin remodeling proteins. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting HELLS in human samples, making it ideal for Western blot and immunohistochemistry applications.HELLS is known to be involved in DNA methylation and gene expression regulation, playing a critical role in chromatin remodeling and epigenetic control. Dysregulation of HELLS expression has been implicated in various diseases, including cancer, developmental disorders, and autoimmune conditions.
By targeting HELLS with this validated antibody, researchers can gain insights into its function and potentially uncover novel therapeutic targets for these diseases.Overall, the KO validated HELLS Polyclonal Antibody (CAB5831) is a reliable tool for researchers looking to study the biological roles of HELLS and its implications in health and disease. Its specificity and sensitivity make it a valuable asset for investigations in molecular biology, genetics, and epigenetics.
Product Name:
[KO Validated] HELLS Rabbit Polyclonal Antibody
SKU:
CAB5831
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 719-838 of human Lsh/HELLS (NP_060533.2).
WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
LSH; ICF4; PASG; SMARCA6; Nbla10143; LS
Positive Sample:
MCF-7,A549,293T,HepG2,Mouse thymus
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
97kDa
Observed MW:
120kDa
This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
3070
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] Lsh/HELLS Rabbit pAb (CAB5831) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
