The KO Validated HDAC1 Rabbit Monoclonal Antibody (CAB19571) is a highly specific and reliable tool for studying HDAC1, a key enzyme involved in gene regulation and epigenetic modifications. This antibody, generated in rabbits, has been extensively validated for knockout (KO) studies, ensuring accurate and reproducible results in research applications such as immunofluorescence, immunoprecipitation, and chromatin immunoprecipitation (ChIP).HDAC1, a member of the histone deacetylase family, is essential for chromatin remodeling and gene expression control. Dysregulation of HDAC1 activity has been linked to various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions.
By targeting HDAC1 with this monoclonal antibody, researchers can effectively analyze its localization, interaction with other proteins, and its role in disease progression.This antibody is particularly valuable for investigators studying epigenetics, gene regulation, and potential therapeutic interventions targeting HDAC1. Its high specificity and sensitivity make it a valuable tool for advancing our understanding of epigenetic mechanisms and developing novel treatments for HDAC1-related diseases.
Product Name:
[KO Validated] HDAC1 Rabbit Monoclonal Antibody
SKU:
CAB19571
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human HDAC1 (Q13547).
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Purification Method:
Affinity purification
Gene ID:
3065
Clone Number:
ARC0050
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] HDAC1 Rabbit mAb (CAB19571) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
